HIF1A and neoplasm: We also work on relieving the hypoxic of tumor by down-regulating the expression of hypoxia inducible factor-1α (HIF-1α) and its downstream vascular endothelial growth factor (VEGF), which was generally believed to be highly expressed in hypoxia (Bergeron et al., 1999; Yee et al., 2009; Long et al., 2012).