Interestingly, the region spanning residues 21–39 mediates the interaction with PALB2, a nuclear protein that promotes the stable intranuclear localization and accumulation of BRCA2, making possible its DNA recombinational repair and checkpoint functions, eliciting tumor suppression (Oliver, Swift, Lord, Ashworth, & Pearl, 2009; Xia et al., 2006). This evidence concerns the gene PALB2 and neoplasm.