Using in‐silico microRNA prediction tools, we shortlisted three miRNAs, of which miR‐338‐5p and miR‐421 revealed an inverse correlation with SPINK1 expression in The Cancer Genome Atlas (TCGA) prostate adenocarcinoma RNA‐Seq dataset, which was validated in our PCa specimens. The gene discussed is SPINK1; the disease is posterior cortical atrophy.