TBP and malignant endocrine neoplasm: Because TATA box binding protein (TBP) is a common binding partner for AF1/NTD of all SHRs and does not bind to the AF2/LBD, yet leads to conformational changes, we hypothesize that TBP‐induced disorder‐order transition opens AF1 surfaces for its interactions with specific coactivators including steroid receptor coactivators‐1 (SRC‐1), a classical SHR coactivator in several endocrine cancers.