Overexpression of Serine Peptidase Inhibitor, Kazal type‐1 (SPINK1) was found to be the second most recurrent ( ̃10%–15%) PCa subtype, after highly recurrent ( ̃50%) androgen‐driven TMPRSS2‐ERG genetic rearrangement. The gene discussed is SPINK1; the disease is posterior cortical atrophy.