An insertion/deletion (I/D) polymorphism in intron 16 of ACE and a single nucleotide polymorphism (SNP) A1166C found in 3'untranslated region (UTR) of AGTR1 are reported to be implicated in various diseases; however their association with Breast Cancer (BCa) is still a topic of debate. The gene discussed is AGTR1; the disease is breast cancer.