The study demonstrated that similar 2-D immunoreactive patterns of TDP-43 at 45 kDa were present in CSF and serum, whereas in brain tissue of ALS patients with TDP-43 pathology, a higher and more acidic pattern was observed at 50 kDa, suggesting post-translational modifications in addition to the full-length form of TDP-43. Here, TARDBP is linked to amyotrophic lateral sclerosis.