The type of concomitant OAD treatment (biguanide or sulfonylurea) did not significantly affect the rate of hypoglycemic events in our study; however, a pooled analysis from 15 treat-to-target randomized controlled trials, where participants received insulin glargine, and metformin, a sulfonylurea, or both, showed that the rates of overall and nocturnal hypoglycemia with insulin glargine plus metformin were generally lowest, while the highest rates were observed in participants treated with insulin glargine combined with both metformin and a sulfonylurea [19]. The gene discussed is INS; the disease is Hypoglycemia.