In insulin-naïve subjects included in the Swedish National Diabetes Register, the mean decrease in HbA1c over 12 months of treatment with basal insulin analogues was 7 ± 17 mmol/mol [14] (0.6 ± 1.5% [15]) for insulin glargine and 7 ± 18 mmol/mol [14] (0.6 ± 1.6% [15]) for insulin detemir. Here, INS is linked to diabetes mellitus.