Remarkably, A-to-I editing of a specific adenosine nucleotide within GRIA2 results in an amino acid change that alters the GluR-2 protein conformation, thus disrupting calcium permeability of the AMPA receptor and potentially contributing to epilepsy, amyotrophic lateral sclerosis (ALS), and schizophrenia (see Oakes et al. 2017). This evidence concerns the gene GRIA2 and amyotrophic lateral sclerosis.