TOMM40 encodes for a beta-barrel protein that ultimately forms a central pore in the outer mitochondrial membrane (Shiota et al. 2015), and much like APOE, genetic variants of TOMM40 are linked to cognitive impairment and neurodegenerative disease (Roses 2010; Gottschalk et al. 2014; Greenbaum et al. 2014; Payton et al. 2016; Roses et al. 2016b; Arpawong et al. 2017). The gene discussed is TOMM40; the disease is neurodegenerative disease.