GDF2 and hereditary hemorrhagic telangiectasia: In fact, virtually all HHT animal studies have focused on the Alk1 and Eng receptor interface of the TGFβ signaling pathway, whereby endothelial loss of Alk1, or Eng or blockade of the TGFβ pathway via Bmp9/10 ligand-blocking antibodies results in HHT-associated phenotypes [16–26].