Additionally, it has been proposed that associations may exist between risk SNPs at 5p15.33, 9p21.3 and 20q13.33 and IDH wild-type glioma [10], as well as 17p13.1 and TERT promoter, IDH mutated glioma without 1p/19q co-deletion [12]. This evidence concerns the gene IDH1 and central nervous system cancer.