Low grade gliomas tend to be EGFR wild-type and p16 wild-type tumours and, therefore, as anticipated many non-GBM risk SNPs were most strongly associated with these tumours; notably 2q33.3 (rs7572263), 3p14.1 (rs11706832), 8q24.21 (rs55705857), 10q25.2 (rs11196067), 11q23.3 (rs12803321) (Supplementary Figs. 7, 8 [Online Resource 1], Supplementary Table 3 [Online Resource 2]). The gene discussed is CDKN2A; the disease is glioblastoma.