Additionally, IPF myofibroblasts showed increase in expression of glycolytic enzymes including 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 (PFKB3), an enzyme that increases levels of fructose-2,6-bisphosphate and drives glycolysis (63). This evidence concerns the gene PFKFB3 and idiopathic pulmonary fibrosis.