Furthermore, the levels of inflammatory cytokines (IL-6, IL-12p70, IFN-γ, TNF-α, and GM-CSF) had peaked at 6 weeks PI, while those of the anti-inflammatory cytokines (IL-4 and IL-10) had peaked at 3 weeks PI, suggesting that levels of the anti-inflammatory cytokines had decreased immediately after the rapid increase during the early stage of infection (Figure 2). The gene discussed is TNF; the disease is infection.