IFNB1 and infection: Infection of BALB/c IFN-β−/− or IFNAR1−/− mice, however, revealed that the clinical development of the skin lesions and the tissue parasite burden were not significantly different from WT BALB/c mice (Figures 6A,D), despite the rapid induction of various type I IFNs (i.e., IFN-α2, IFN-α4, IFN-α5, IFN-α6, and IFN-α9) at the site of infection in BALB/c WT mice (see Figure 7, upper panel, PBS/L.