While we did not detect clear signatures of regulatory T cell activation in the spleen, two genes potentially involved in immune regulation correlated strongly with parasite burdens: IL17RA, as mentioned above, and ACKR3, a chemokine scavenger (82) that is widely expressed in the hematopoietic system, heart, vascular endothelial cells, bone, kidney, and brain, and that is reported to be upregulated in many cancers (83) and also mimicked by a herpesvirus agonist (84, 85). The gene discussed is IL17RA; the disease is cancer.