GSTM1 and systemic inflammatory response syndrome: Many CIR-miRNAs, including miR-378a-3p, miR-30a-5p, miR-30d-5p, and miR-192-5p (Figure 4A) and miR-101-3p, miR-21-5p, miR-22-3p, miR-423-5p, and miR-122-5p (Figure S4 in Supplementary Material) significantly inversely correlated with free Hb levels even after a stringent Benjamini–Hochberg correction (52), supporting that CIR-miRNAs relevant in severe SIRS do not derive from RBCs.