In addition, CIR-miRNAs in comparison to IL-6, CRP, PCT, and free Hb, generally showed more robust correlations with the APACHE II score, while IL-8 and Prdx-1 had significant positive correlation with the APACHE II score in non-infective SIRS (Figure S2A in Supplementary Material), but not in sepsis (Figure S2B in Supplementary Material). Here, CRP is linked to systemic inflammatory response syndrome.