In this study, we have further extended our previous analysis of a single center cohort of KTRs by (i) analyzing 128 additional skin lesions excised from 29 KTRs; (ii) correlating ΔNp63 expression levels with those of E4 and MCM7 in skin areas of productive HPV infection; and (iii) establishing and characterizing patient-derived xenografts as models to study skin cancer progression of β-HPV-infected skin lesions. The gene discussed is MCM7; the disease is skin cancer.