However, an interesting study of cells derived from a patient with Danon disease, of which LAMP2a deficiency is a central feature, reported that α-synuclein in patient-derived lymphoblastoid cells was not elevated, challenging the idea that LAMP2a function primarily mediates α-synuclein autophagy under normal conditions (Sanchez-Lanzas et al., 2016). The gene discussed is SNCA; the disease is Danon disease.