CACNA1D and Parkinson disease: We show that these dopamine-induced changes were reversed by treating the cells with isradipine, a CaV1.3 calcium channel antagonist previously reported to block dopaminergic neuron cell death in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) and other neurotoxin-related Parkinson’s disease models24.