ADIPOQ and obesity due to melanocortin 4 receptor deficiency: The mutations and genes identified by our SWIF(r) scan, such as ADIPOQ, are natural targets for functional assays to determine the origins and consequences of subcutaneous vs. visceral fat; future studies could merge such assays with phenotypic data on diabetes and metabolic syndromes in KhoeSan groups to gain new insight into the “obesity-mortality paradox”50.