Several established oncogenic signaling pathways, including Wnt/β-catenin signaling, MAPK cascade, transforming growth factor (TGF)-β/bone morphogenetic protein (BMP) signaling, and platelet-derived growth factor (PDGF) signaling, were universally perturbed by dysregulated miRNAs in all three types of cancer. The gene discussed is TGFB1; the disease is cancer.