Early series of GWAS and meta-GWAS in European ancestry populations identified 10 AF-susceptibility loci, including SNPs rs2200733 and rs10033464 near PITX2c gene, rs2106261 and rs7193343 in ZFHX3, rs13376333 in KCNN3, rs593479 in PRRX1, rs3807989 in CAV1, rs6479562 in C9orf3, rs10824026 in SYNPO2L, rs1152591 in SYNE2, rs7164883 located in HCN4 and rs2040862 in WNT8A12–16. The gene discussed is ZFHX3; the disease is atrial fibrillation.