We carried out a case control association study for AF with four SNPs, including SNP rs4642101 within the CAND2 gene on chromosome 3p25.2, rs13216675 close to the GJA1 gene on chromosome 6q22.3, rs6584555 near the NEURL gene on chromosome 10q24.33 and rs6490029 within the CUX2 gene on chromosome 12q24.11. The gene discussed is CUX2; the disease is atrial fibrillation.