From the OncoPrint of the TCGA oesophageal-stomach cancers sample, a total of seven genes had greater than 10.0% - alterations frequency and those with the highest frequency were: ERBB2 (25.0%), JUP (15.0%), CUL7 (13.0%), RAB22A (12.0%), CPSF4 (11.0%), FADD (11.0%), IQGAP1 (11.0%), KRAS (11.0%) and LASP1 (10.0%). The gene discussed is IQGAP1; the disease is gastric cancer.