Since deficiency of Psgl-1 has been shown to dampen endothelial responses to cytokines via reduced activation of NFκB10 and to protect against obesity-induced endothelial dysfunction13, we therefore sought to determine whether Psgl-1 deficiency could attenuate the pressor effect of Ang II since Ang II can also activate NFκB pathway via angiotensin-type 1 receptor (AT1R) signaling. The gene discussed is SELPLG; the disease is obesity due to melanocortin 4 receptor deficiency.