The phenotype we observe in Ad-B2(−/−) mice, using the Adiponectin-Cre line, contrasts with a previous report using the aP2-Cre line to knock out seipin, which concluded that seipin loss in adipocytes resulted in a progressive lipodystrophy with apparently normal adipose tissue development in early life [26]. Here, ADIPOQ is linked to lipodystrophy.