The expression of the genes involved in adhesion, biofilm initiation and maturation, and formation of C. albicans hyphae (Fig. 5a; agglutinin-like sequences, ALS1, ALS3; epithelial adhesin 1, EPA1) was increased in mixed-species biofilms relative to C. albicans-only biofilms, and showed little difference between the different tissue infections, with the exception of ALS1 in the MatTek EpiOral infections, where a decrease in expression was observed. The gene discussed is SOD1; the disease is infection.