S100A8 and gastric cancer: Evidence indicates that the isoform s1m1 of vacA, the presence of the babA2 gene, and the type and number of the EPIYA motifs that characterize the cagA variants, are involved in the type and magnitude of the histological damage of the mucosa, for example, the vacA s1m1 genotype has been associated with intestinal metaplasia, severe inflammation and high risk of gastric cancer [35].