SORL1 and Alzheimer disease: TRAPPC12-AS1 is an antisense (noncoding) RNA that contains a 1168 transcript from TRAPPC12. We previously established that regulation of vesicular trafficking in the ER to Golgi by several VPS10 receptor domain receptor genes, including SORL1, and by other genes encoding members of the retromer complex is an important pathway leading to AD [48–50].