The majority of the glioma-associated lncRNAs serve as “miRNA sponges” to quench miRNA activity (e.g., HOTAIR/miR-326 [43], Gas5/miR-196a-5p [44], CASC2/ miR-181a [45] and ECONEXIN /miR-411-5p [46]). This evidence concerns the gene CASC2 and central nervous system cancer.