In our own studies [56, 79], expression array and RNAseq experiments reveal broad and marked induction of IFN-stimulated genes including CXCL10 in HNSCC cell lines and EGFR mutant lung cancer cell lines treated with EGFR inhibitors as well as EML4-ALK-driven cell lines treated with crizotinib. This evidence concerns the gene ALK and head and neck squamous cell carcinoma.