However, in other studies, induction of a Gas6-AXL pathway associated with EMT was shown to mediate EGFR TKI-induced resistance in lung cancer [51, 52] to cetuximab and erlotinib in HNSCC [53, 54] and to ALK inhibitors in ALKF1174L-positive human neuroblastoma cells [55]. The gene discussed is ALK; the disease is head and neck squamous cell carcinoma.