TGFB1 and neoplasm: For example, Bedi et al. [68] showed that tumor cell-expressed TGFβ exerts an extrinsic inhibition of the cytotoxic function of immune effectors by suppressing the expression of key molecular effectors including Apo2L/TRAIL, CD95L/FasL, granzyme B, and interferon gamma (IFNγ).