Similarly, another versatile PSCs/MDSCs derived pro-inflammatory cytokine, interleukine-6 (IL-6), can suppress cytotoxic T lymphocyte (CTL)-driven antitumor immunity by multiple mechanisms, including impairing Teff cells trans-endothelial migration, activation of Treg cells Foxp3+ or tumor-associated macrophages (TAMs), and inducing imbalance of Treg/ Teff activities [149, 150]. Here, IL6 is linked to neoplasm.