Meanwhile, confronted with “metabolic competition”, lack of glucose impairs T cell’s anti-tumor immunity and secretion of Interferon-γ (IFN-γ) [141, 142], while low lipid support results in TNF receptor associated factor 6 (TRAF6) deficiency, which inhibits long-lasting memory CD8+ T cells formation [143]. Here, TRAF6 is linked to neoplasm.