The results of subgroup analysis showed that AA vs AG + GG (OR = 0.77, 95%CI = 0.62–0.95, P < 0.05), AA vs GG (OR = 0.55, 95%CI = 0.32–0.92, P < 0.05), and A vs G (OR = 0.78, 95%CI = 0.64–0.97) of CCL2-2518A/G (rs1024611) were all associated with the reduced risk of gynecological cancer in Asians (Fig. 3a–e), There was also a reduced risk of gynecological cancer in AA genotype compared with GG (OR = 0.59, 95%CI = 0.38–0.92). Here, CCL2 is linked to female reproductive organ cancer.