Subsequently, the recruited monocytes transform into TAMs stimulated by cell factors (like macrophage colony-stimulating factor (M-CSF), vascular permeability factor (VEGF)-1, IL-4, IL-10, IL-13), and then, tumor angiogenesis is induced by TAM-secreted angiogenesis factors (Fig. 5) [22, 23]. The gene discussed is IL10; the disease is neoplasm.