SYVN1 and Central diabetes insipidus: In a recent study, we reported that proAVP, the ER precursor for the antidiuretic hormone AVP, also requires ERAD activity of the Sel1L-Hrd1 protein complex for its conformational maturation, and mice with inducible or AVP neuron-specific Sel1L deletion develop central diabetes insipidus, a condition caused by AVP deficiency (39).