Its use as a predictive biomarker has also been noted in CKD patients because it has been found to be markedly elevated, especially in hemodialysis patients [12] because NT-proBNP is degraded by the kidney, whose function is almost totally diminished in hemodialysis patients, and proBNP is also degraded by adipose tissue, which is sometimes much lower in hemodialysis patients [13]. The gene discussed is NPPB; the disease is chronic kidney disease.