TNFSF11 and periodontal disorder: Pth from the circulation or give therapeutically as terapeptide, can play a critical role in inhibiting Sclerostin and stimulating remodeling, We know that the osteocyte under normal physiological conditions, is a major source of the macrophage to osteoclast differentiation RankL factor [10] However, under pathological conditions of inflammatory induced bone loss in periodontal disease, a major local production of RankL comes from activated T and B cells that stimulate macrophage to osteoclast differentiation, leading to bone loss.