Lyme disease and relapsing fever spirochetes produce several plasminogen-interacting proteins, e.g., OspA, OspC, the Borrelia-plasminogen-binding protein BPBP, enolase, CRASPs (CspA, CspZ, ErpA, ErpC, ErpA), and BBA70 of B. burgdorferi (Fuchs et al., 1994; Brissette et al., 2009; Hallström et al., 2010; Floden et al., 2011; Onder et al., 2012; Koenigs et al., 2013) as well as BhCRASP-1 of B. hermsii (Rossmann et al., 2007), HcpA of B. recurrentis (Grosskinsky et al., 2009), and BpcA of B. parkeri (Schott et al., 2010). This evidence concerns the gene ENO1 and disease recurrence.