Lyme disease and relapsing fever spirochetes produce several plasminogen-interacting proteins, e.g., OspA, OspC, the Borrelia-plasminogen-binding protein BPBP, enolase, CRASPs (CspA, CspZ, ErpA, ErpC, ErpA), and BBA70 of B. burgdorferi (Fuchs et al., 1994; Brissette et al., 2009; Hallström et al., 2010; Floden et al., 2011; Onder et al., 2012; Koenigs et al., 2013) as well as BhCRASP-1 of B. hermsii (Rossmann et al., 2007), HcpA of B. recurrentis (Grosskinsky et al., 2009), and BpcA of B. parkeri (Schott et al., 2010). Here, PLG is linked to Lyme disease.