ARHGEF10 and Anxiety: The time spent in the open arms was significantly increased in Arhgef10 knockout mice (open arms: F1,23 = 11.04, p = 0.003; closed arms: F1,23 = 14.481, p = 0.001, n = 13 for WT vs Arhgef10 KO) (Fig. 4a), indicating that anxiety-like behavior was reduced in knockout mice.