The changes in cardiac function with glucagon-like peptide-1 receptor agonist, in combination with our current findings with acute vitamin C, suggest that the T2D associated exercise impairment in people with uncomplicated, well controlled T2D, could be related to skeletal muscle oxidative function, which has been reported by our group and others [2, 7, 35, 36]. The gene discussed is GLP1R; the disease is type 2 diabetes mellitus.