Supplementation of the RTC diet with canolol reversed the situation, preventing the overexpression of Ag2R-1b and occurrence of ischemia, as demonstrated by the reductions in fibrosis (collagen content restored to levels observed with the R diet), metabolic dysfunctions (re-activation of β-oxidation and glucose degradation rates) and oxidative stress (decrease in SOD2 mRNA expression). Here, SOD2 is linked to ischemia.