PLEKHS1 and cancer: More recently, mutations in the regulatory regions of other cancer-related genes have been identified, including recurrent mutations in the promoters of PLEKHS1, WDR74, SDHD, and FOXA1 that alter gene expression levels, TF binding and that are associated with poor prognosis (Fredriksson et al., 2014; Weinhold et al., 2014; Nik-Zainal et al., 2016; Rheinbay et al., 2017).