For example, a recent study analyzing 863 human tumors has identified recurrent mutations in regulatory elements upstream of TERT, PLEKHS1, WDR74 and SDHD in different types of cancer by using 50 bp windows to find hotspots, and regional recurrence approaches that take into account length and replication timing (Weinhold et al., 2014). The gene discussed is PLEKHS1; the disease is cancer.