TP53 and cancer: Similar to other cancer types, TP53-mutant HCCs have been associated with features linked to poor prognosis, including high levels of alpha-fetoprotein, high Edmondson grade, expression of stem-like markers, and activation of pro-oncogenic signaling pathways (Kiani et al., 2002; Breuhahn et al., 2004; Lee et al., 2004; Peng et al., 2004; Boyault et al., 2007; Chiang et al., 2008; Hoshida et al., 2009; Goossens et al., 2015).