TP53 and hepatocellular carcinoma: As for 8q24, in addition to the well-known oncogenic role of MYC, previous studies have also shown that MYC amplification is an indicator of malignant potential and poor prognosis in HCC (Lin et al., 2010), and that the co-occurrence of MYC amplification and p53 alteration may contribute to HCC progression (Kawate et al., 1999).