TP53 and hepatocellular carcinoma: In HCC, TP53 mutational frequency has been reported to range between 22 and 33% (Fujimoto et al., 2012; Guichard et al., 2012; Cleary et al., 2013; Kan et al., 2013; Ahn et al., 2014; Jhunjhunwala et al., 2014; Shiraishi et al., 2014; Totoki et al., 2014; Weinhold et al., 2014; Schulze et al., 2015; Fujimoto et al., 2016; The Cancer Genome Atlas Research Network, 2017).