We examined whether MDSCs, defined as HLA-DRlo/− cells in monocytes gated by CD33+CD11b+CD14+CD66b− (35, 50), were expanded in tumor-bearing HSC-NOG-hIL-6 Tg mice; however, we failed to detect increased numbers of HLA-DRlo/− cells in spleen and PB. The gene discussed is CD33; the disease is neoplasm.