To investigate whether TAM-like cells differentiated in humanized mice have similar immunosuppressive functions to those in cancer patients, Arg-1 expression in CD14+CD68+ monocytes/macrophages was analyzed in the tumor, spleen, and PB of HSC-NOG-hIL-6 Tg mice or HSC-NOG non-Tg mice. Here, CD68 is linked to neoplasm.