Consistent with this finding, we observed rIL-18 restricts Salmonella translocation at 48 h p.i. However, MLKL−/− epithelium had a modest higher bacterial burden at the acute stage of infection (6 h p.i.); it is probable that pyroptosis rather than IL-18 contributes to MLKL-mediated protection against early Salmonella epithelial colonization. Here, MLKL is linked to infection.