Using a colitis model, we found that MLKL−/− mice were more sensitive to Salmonella-induced colitis, as indicated by increased mortality, body weight loss, and intestinal-associated pathologic changes including cecal weight loss, goblet cells loss, submucosal edema, PMN infiltration, complete destruction of epithelial integrity, and pro-inflammatory mediator production. Here, MLKL is linked to colitis.