Thus, STAT3 has been regarded as a key target for lung cancer prevention (Dutta et al., 2014; Harada et al., 2014), and inhibition of STAT3 signal showed great anticancer and antiangiogenic effects in vitro and in vivo (Yang et al., 2012; Xu and Zhu, 2017). This evidence concerns the gene STAT3 and lung carcinoma.