PTCH1 and colorectal neoplasm: When looking for a possible translational relevance of these discoveries, one may hypothesize that subsets of colorectal tumors endowed with abnormal Hh signaling due to mutations, such as a recently reported PTCH1 loss-of-function mutation (Chung and Bunz, 2013), that may not have been represented in the cohorts previously treated with Hh inhibitors (Berlin et al., 2013), may benefit from drugs inhibiting Hh activity such as GDC-0449.