High fructose fed rats were reported to have decreased GLO1 activity [20], and in a recent metabolomics study, LDLR−/− mice with high fat diet-induced NASH showed an 83% decrease in hepatic content of S-D-lactoyl-glutathione, consistent with a marked decrease in GLO1 activity [21]. The gene discussed is LDLR; the disease is metabolic dysfunction-associated steatohepatitis.