BCL2L1 and cancer: Heterogeneous nuclear ribonucleoprotein 1, a component of nuclear ribonucleoprotein complexes, is involved in the biogenesis of mRNA, by alternative splicing of the apoptotic mediator Bcl-x [44]; in cancer, it has been found overexpressed, and highly phosphorylated phenotypes correlated with HER2 positive cancer [45].