The two main commercially available amplicon-based methods are the Ion AmpliSeq RNA Lung Cancer Research Fusion Panel (Thermo Fisher Scientific, Waltham, MA, USA) and the Archer® FusionPlex® ALK, RET, ROS1 v2 kit (ArcherDX, Boulder, CO, USA) (Fig. 2d). Here, ALK is linked to lung carcinoma.