PIK3CA and breast carcinoma: Dual PI3K/mTOR inhibitors in advanced clinical trials include NVP-BEZ235 (glioblastomas) [184], XL765 (breast cancer) [185], GDC0980 (mRCC) [186], PF04691502 (breast cancer) [187], GSK2126458 (colorectal, breast, non-small cell lung, and pancreatic cancers) [188], Quinacrine (various leukemias) [189, 190] and PKI587 (advanced solid malignancies) [191].