Furthermore, RET gain-of-function point mutations were also observed in up to 50% of sporadic medullary thyroid cancers [60] and the occurrence of germline mutations predispose patients to multiple endocrine neoplasia type 2 characterized by medullary thyroid cancer, pheochromocytoma and hyperparathyroidism [61]. This evidence concerns the gene RET and medullary thyroid gland carcinoma.