In in vivo study mice bearing drug resistant leukemia cell lineK562/ADM(Adriamycin) Haishengsu acted by repressing levels of multi drug resistant gene-1 (mdr1), BCR-ABL and sorcin at dose of 1800 mg/kg which was significant in comparison to group that received no drug (control) and that received adriamycin and haishengsu in combination [213]. This evidence concerns the gene ABL1 and leukemia.