Later identification of the fusion oncoprotein BCR–ABL1 formed by chromosome translocation, t(9;22)(q34.1;q11.2), commonly identified as Philadelphia chromosome (Ph) confirmed the role of Abl family in cancers such as acute myeloid leukemia (AML), chronic myeloid leukemia (CML), and acute lymphoblastic leukemia (ALL), all of which are hematological malignancies. Here, ABL1 is linked to acute lymphoblastic leukemia.