BCR and chronic myelogenous leukemia, BCR-ABL1 positive: Chlorgenic acid  (Fig. 2h)is isolated from leaves of Piper betel promoted cell death by hindering expression of BCR-ABL and c-Abl kinases through activation of p38 and ERK-MAP kinase in cells bearing positive BCR-ABL and in BCR-ABL–positive leukemic cells isolated from CML patients in vitro.