Tec family kinases, the second largest subfamily of the NRTKs, consist of five members, including BTK (Bruton’s tyrosine kinase), ITK/EMT/TSK (interleukin 2-inducible T-cell kinase), RLK/TXK (tyrosine-protein kinase), BMX/ETK (bone marrow tyrosine kinase on chromosome) and Tec (tyrosine kinase expressed in hepatocellular carcinoma) [107]. Here, TXK is linked to hepatocellular carcinoma.