Also during the last decade, a number of genetic alterations have been described in NSCLC, being Kristen Rat Sarcoma viral oncogene (KRAS), Epidermal Growth Factor Receptor (EGFR) and Anaplastic Lymphoma Kinase (ALK) the most commonly altered oncogenes acting as tumor genomic drivers [10]. The gene discussed is KRAS; the disease is neoplasm.