Inhibition of mTORC1/2 signaling, using pharmalogical inhibitors or knockdown of mTORC1/RAPTOR and mTORC2/RICTOR, attenuated migration and invasion of CRC cells, induced a mesenchymal–epithelial transition and enhanced chemosensitivity of CRC cells to oxaliplatin [40]. The gene discussed is RPTOR; the disease is colorectal carcinoma.