Moreover, in absence of gene amplification, RICTOR overexpression can also be associated with the deregulation of miRNA expression in tumoral cells such as miR-218 in prostate and oral cancers, the miR-424/503 cluster in colon cancers, and miR-196b in melanoma and hepotocellular carcinoma [42, 47, 51, 52]. Here, RICTOR is linked to melanoma.