In pancreatic tumors, it was shown that RICTOR blockage led to an inhibition of hypoxia-induced factor-1α (HIF-1α) expression and a significant reduction of its downstream target vascular-endothelial growth factor-A (VEGF-A), a critical cancer-promoting factor involved in the recruitment of stromal cells [35]. The gene discussed is RICTOR; the disease is pancreatic neoplasm.